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var(--tw-shadow-color,#0000001a);box-shadow:var(--tw-inset-shadow),var(--tw-inset-ring-shadow),var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow);background-color:var(--op-lilac);flex-direction:column;justify-content:flex-end;align-items:flex-start;min-height:26.9rem;display:flex;position:relative}.basic-card .basic-card-content{width:100%;padding:calc(var(--spacing)*0)}.basic-card{border-radius:var(--radius-2xl);border-style:var(--tw-border-style);border-width:1px;border-color:var(--op-grey-2);height:100%;padding:1.5rem;display:flex}.browse-and-edition-icons{align-items:center;gap:calc(var(--spacing)*2);display:flex}.browse-and-edition-saved-container .browse-and-edition-saved-message-date{margin-block:calc(var(--spacing)*0);font-family:ff-scala-sans-pro,arial,sans-serif;font-size:var(--text-xs);line-height:var(--tw-leading,var(--text-xs--line-height));color:var(--op-grey-5)}.browse-and-edition-saved-container .browse-and-edition-saved-message-date 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.article-card-title{font-size:var(--text-lg);line-height:var(--tw-leading,var(--text-lg--line-height))}.view-more-carousel-desktop-card-container{margin-bottom:calc(var(--spacing)*1);justify-content:center;align-items:center;gap:calc(var(--spacing)*4);background-color:var(--op-grey-5);padding:calc(var(--spacing)*4)}.view-more-editions-mobile-card-container>span{font-size:var(--text-base);line-height:var(--tw-leading,var(--text-base--line-height));--tw-leading:var(--leading-tight);line-height:var(--leading-tight);text-align:center;--tw-font-weight:var(--font-weight-medium);font-family:Lyon Display 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var(--tw-shadow-color,#0000001a);min-height:15.875rem;box-shadow:var(--tw-inset-shadow),var(--tw-inset-ring-shadow),var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow);justify-content:center;align-items:center;gap:calc(var(--spacing)*4);background-color:var(--op-grey-5);height:100%;min-height:12.375rem;padding:calc(var(--spacing)*4);flex-direction:column;display:flex;position:relative}.browse-specialty-topic-article-card-container.specialty-topic-carousel{height:100%}.browse-specialty-topic-article-card-container>.browse-specialty-topic-summary-text-lg{--tw-leading:2.25rem;font-size:2.3rem;line-height:2.25rem}.browse-specialty-topic-article-card-container>.browse-specialty-topic-summary-text-md{--tw-leading:2.25rem;font-size:2rem;line-height:2.25rem}.browse-specialty-topic-article-card-container>.browse-specialty-topic-summary-text-sm{--tw-leading:2.25rem;font-size:1.3rem;line-height:2.25rem}.browse-specialty-topic-article-card-container{margin-bottom:calc(var(--spacing)*1);border-radius:var(--radius-2xl);background-color:var(--op-white);min-height:15.875rem;padding:calc(var(--spacing)*4);--tw-shadow:0 1px 3px 0 var(--tw-shadow-color,#0000001a),0 1px 2px -1px var(--tw-shadow-color,#0000001a);box-shadow:var(--tw-inset-shadow),var(--tw-inset-ring-shadow),var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow);text-align:center;--tw-font-weight:var(--font-weight-normal);font-family:Lyon Display Web,Georgia,serif;font-weight:var(--font-weight-normal);color:var(--op-white);flex-direction:column;justify-content:center;align-items:center;display:flex;position:relative}.carousel-item{padding-bottom:calc(var(--spacing)*2)}@media (min-width:40rem){.carousel-item{flex-basis:50%!important}}@media (min-width:48rem){.carousel-item{flex-basis:33.3333%!important}}@media (min-width:64rem){.carousel-item{flex-basis:25%!important}}@media (min-width:40rem){.weekly-index-carousel-item{flex-basis:100%!important}}@media (min-width:48rem){.weekly-index-carousel-item{flex-basis:50%!important}}@media 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100%}}.not-found-articles-container{margin-bottom:calc(var(--spacing)*2);border-radius:var(--radius-lg);background-color:var(--op-white);padding-block:calc(var(--spacing)*8);text-align:center;grid-column:span 12/span 12}.not-found-articles-container .headline-h4{font-size:var(--text-2xl);line-height:var(--tw-leading,var(--text-2xl--line-height));--tw-leading:1.95rem;color:var(--op-grey);line-height:1.95rem}.not-found-container .not-found-header{margin-bottom:calc(var(--spacing)*4);font-family:Lyon Display Web,Georgia,serif;font-size:var(--text-4xl);line-height:var(--tw-leading,var(--text-4xl--line-height));--tw-font-weight:var(--font-weight-medium);font-weight:var(--font-weight-medium)}.not-found-container .not-found-content-container .not-found-content-header{font-family:Lyon Display Web,Georgia,serif;font-size:var(--text-2xl);line-height:var(--tw-leading,var(--text-2xl--line-height));--tw-font-weight:var(--font-weight-medium);font-weight:var(--font-weight-medium)}.not-found-container 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.headline-h4{font-size:var(--text-2xl);line-height:var(--tw-leading,var(--text-2xl--line-height));--tw-leading:1.95rem;color:var(--op-grey);line-height:1.95rem}.sign-in-container .sign-in-header{margin-bottom:calc(var(--spacing)*4);font-family:Lyon Display Web,Georgia,serif;font-size:var(--text-4xl);line-height:var(--tw-leading,var(--text-4xl--line-height));--tw-font-weight:var(--font-weight-medium);font-weight:var(--font-weight-medium)}.sign-in-container .sign-in-content-container .sign-in-content-header{font-family:Lyon Display Web,Georgia,serif;font-size:var(--text-2xl);line-height:var(--tw-leading,var(--text-2xl--line-height));--tw-font-weight:var(--font-weight-medium);font-weight:var(--font-weight-medium)}.sign-in-container .sign-in-content-container p{margin-bottom:calc(var(--spacing)*4)}.sign-in-container 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.eotwe-title{--tw-leading:3.25rem;font-size:2.5rem;line-height:3.25rem}}.end-of-this-weeks-edition-wrapper .eotwe-container .eotwe-subtitle-container .eotwe-subtitle-icon{color:var(--op-white)}@media not all and (min-width:31.875rem){.end-of-this-weeks-edition-wrapper .eotwe-container .eotwe-subtitle-container .eotwe-subtitle-icon{width:calc(var(--spacing)*5);height:calc(var(--spacing)*5)}}@media (min-width:31.875rem){.end-of-this-weeks-edition-wrapper .eotwe-container .eotwe-subtitle-container .eotwe-subtitle-icon{width:calc(var(--spacing)*6);height:calc(var(--spacing)*6)}}@media not all and (min-width:21.875rem){.end-of-this-weeks-edition-wrapper .eotwe-container .eotwe-subtitle-container .eotwe-subtitle-text .eotwe-subtitle-date{display:block}}.end-of-this-weeks-edition-wrapper .eotwe-container .eotwe-subtitle-container .eotwe-subtitle-text 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(min-width:31.875rem){.end-of-this-weeks-edition-wrapper .eotwe-container .eotwe-links-container{gap:calc(var(--spacing)*4);flex-direction:column}}@media (min-width:31.875rem){.end-of-this-weeks-edition-wrapper .eotwe-container .eotwe-links-container{gap:calc(var(--spacing)*8);flex-direction:row}}.end-of-this-weeks-edition-wrapper .eotwe-container{padding-inline:calc(var(--spacing)*4);color:var(--op-white);flex-direction:column;justify-content:space-evenly;align-items:center;display:flex}@media not all and (min-width:31.875rem){.end-of-this-weeks-edition-wrapper .eotwe-container{padding-block:calc(var(--spacing)*6)}}@media (min-width:31.875rem){.end-of-this-weeks-edition-wrapper .eotwe-container{border-radius:var(--radius-2xl);padding-block:calc(var(--spacing)*16)}}.end-of-this-weeks-edition-wrapper{grid-column:span 12/span 12;width:100%}@media not all and 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.filter-count{width:calc(var(--spacing)*6);height:calc(var(--spacing)*6);background-color:var(--nejm-red);color:var(--op-white);border-radius:3.40282e38px;margin-inline-end:calc(var(--spacing)*2);text-decoration-line:none}.filter-items-manager-container .filter-selector{border-style:var(--tw-border-style);border-width:0;border-bottom-style:var(--tw-border-style);width:100%;padding:calc(var(--spacing)*0);padding-top:calc(var(--spacing)*1);padding-bottom:calc(var(--spacing)*2);font-size:var(--text-base);line-height:var(--tw-leading,var(--text-base--line-height));border-bottom-width:1px;border-radius:0}.filter-items-manager-container .filter-cme-checkbox-form-item,.filter-items-manager-container 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.filtered-keywords-container,.filter-items-manager-container .filtered-keywords-title{white-space:normal;word-break:break-word;overflow-wrap:anywhere}}@property --tw-animation-delay{syntax:"*";inherits:false;initial-value:0s}@property --tw-animation-direction{syntax:"*";inherits:false;initial-value:normal}@property --tw-animation-duration{syntax:"*";inherits:false}@property --tw-animation-fill-mode{syntax:"*";inherits:false;initial-value:none}@property --tw-animation-iteration-count{syntax:"*";inherits:false;initial-value:1}@property --tw-enter-blur{syntax:"*";inherits:false;initial-value:0}@property --tw-enter-opacity{syntax:"*";inherits:false;initial-value:1}@property --tw-enter-rotate{syntax:"*";inherits:false;initial-value:0}@property --tw-enter-scale{syntax:"*";inherits:false;initial-value:1}@property --tw-enter-translate-x{syntax:"*";inherits:false;initial-value:0}@property --tw-enter-translate-y{syntax:"*";inherits:false;initial-value:0}@property --tw-exit-blur{syntax:"*";inherits:false;initial-value:0}@property --tw-exit-opacity{syntax:"*";inherits:false;initial-value:1}@property --tw-exit-rotate{syntax:"*";inherits:false;initial-value:0}@property --tw-exit-scale{syntax:"*";inherits:false;initial-value:1}@property --tw-exit-translate-x{syntax:"*";inherits:false;initial-value:0}@property --tw-exit-translate-y{syntax:"*";inherits:false;initial-value:0}:root{--twsa-safe-area-inset-top:env(safe-area-inset-top);--twsa-safe-area-inset-right:env(safe-area-inset-right);--twsa-safe-area-inset-bottom:env(safe-area-inset-bottom);--twsa-safe-area-inset-left:env(safe-area-inset-left)}@font-face{font-weight:300;font-family:Lyon Display Web;font-style:normal;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonDisplay-Light-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon/LyonDisplay-Light-Web.woff)format("woff")}@font-face{font-weight:300;font-family:Lyon Display 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Web;font-style:italic;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonText-RegularItalic-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon//LyonText-RegularItalic-Web.woff)format("woff")}@font-face{font-weight:500;font-family:Lyon Text Web;font-style:normal;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonText-RegularNo2-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon/LyonText-RegularNo2-Web.woff)format("woff")}@font-face{font-weight:500;font-family:Lyon Text Web;font-style:italic;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonText-RegularNo2Italic-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon/LyonText-RegularNo2Italic-Web.woff)format("woff")}@font-face{font-weight:600;font-family:Lyon Text Web;font-style:normal;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonText-Semibold-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon/LyonText-Semibold-Web.woff)format("woff")}@font-face{font-weight:600;font-family:Lyon Text Web;font-style:italic;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonText-SemiboldItalic-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon/LyonText-SemiboldItalic-Web.woff)format("woff")}@font-face{font-weight:700;font-family:Lyon Text Web;font-style:normal;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonText-Bold-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon/LyonText-Bold-Web.woff)format("woff")}@font-face{font-weight:700;font-family:Lyon Text Web;font-style:italic;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonText-BoldItalic-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon/LyonText-BoldItalic-Web.woff)format("woff")}@font-face{font-weight:900;font-family:Lyon Text Web;font-style:normal;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonText-Black-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon/LyonText-Black-Web.woff)format("woff")}@font-face{font-weight:900;font-family:Lyon Text Web;font-style:italic;font-stretch:100%;src:url(https://fonts.nejmgroup-dev.org/lyon/LyonText-BlackItalic-Web.woff2)format("woff2"),url(https://fonts.nejmgroup-dev.org/lyon/LyonText-BlackItalic-Web.woff)format("woff")}@media (max-width:79.999rem){@layer components{.ad-space-right-margin.ad-space-mobile>img,.ad-space-right-margin.ad-space-mobile .ad-space-advertisement-label{width:calc(100vw - 15%);max-width:18.75rem;height:auto;margin-inline:auto}.ad-space-right-margin.ad-space-mobile{margin-left:calc(var(--spacing)*0);max-width:100%;min-width:calc(var(--spacing)*0)}.ad-space-top-margin.ad-space-mobile>img{width:calc(100vw - 15%);max-width:19.375rem;height:auto;max-height:2.5rem;margin-inline:auto}.ad-space-top-margin.ad-space-mobile>span{margin-right:calc(var(--spacing)*0);display:block;rotate:none}.ad-space-top-margin.ad-space-mobile{height:auto;margin-inline:auto;display:block}}}@media (min-width:64rem){@layer components{.article-card-browse-all{margin-bottom:calc(var(--spacing)*1)}}}@media (max-width:79.999rem){@layer components{.site-nav .nav-tablet-logo-account-container{width:100%;padding-block:calc(var(--spacing)*2);justify-content:space-between;align-items:center;display:flex}.site-nav .nav-tablet-nav-links-container{width:100%;padding-top:calc(var(--spacing)*3);justify-content:center;align-items:flex-end;display:flex}.site-nav{width:100%;height:auto}}}@media (max-width:21.874rem){@layer components{.nav-logo-link-sm .nav-logo-link{width:9rem}.nav-logo-link-sm .nav-logo-link>svg{height:1.75rem}.nav-logo-link-sm{margin-top:calc(var(--spacing)*.5)}}}@media (min-width:80rem){@layer components{.site-nav>.nav-links-container>a,.site-nav>.nav-links-container button{padding-block:calc(var(--spacing)*1)}.site-nav{width:100%;height:5.125rem;min-height:5.125rem;padding-block:calc(var(--spacing)*2);justify-content:space-between;align-items:center;display:flex}}}.nejm-widget-header-container.no-borders .nejm-widget-header{padding-block:calc(var(--spacing)*0)}.nejm-widget-header-container.no-borders{margin-bottom:calc(var(--spacing)*2);--tw-border-style:none;border-style:none}.nejm-widget-header-container .nejm-widget-header{--tw-leading:1.5rem;--tw-font-weight:var(--font-weight-bold);font-size:1rem;line-height:1.5rem;font-weight:var(--font-weight-bold);--tw-tracking:.02rem;letter-spacing:.02rem;color:var(--nejm-black);text-transform:uppercase;padding-block:.94rem;display:block}.nejm-widget-header-container{margin-bottom:calc(var(--spacing)*4);border-top-style:var(--tw-border-style);border-top-width:.125rem;border-bottom-style:var(--tw-border-style);--tw-border-style:solid;border-style:solid;border-bottom-width:.0625rem;border-color:var(--op-grey-5)}@media (min-width:80rem){@layer components{.article-with-right-rail-container{flex-direction:row;justify-content:space-between;display:flex}}}@media (max-width:31.874rem){@layer components{.article-title-content .article-meta-mobile{display:flex}.article-title-content .article-meta-tablet,.article-title-content .article-meta-desktop{display:none}}}@media (min-width:31.875rem) and (max-width:79.999rem){@layer components{.article-title-content .article-meta-mobile,.article-title-content .article-meta-desktop{display:none}.article-title-content .article-meta-tablet{display:flex}}}@media (min-width:80rem){@layer components{.article-title-content .article-meta-mobile,.article-title-content .article-meta-tablet{display:none}.article-title-content .article-meta-desktop{display:flex}}}@media (max-width:39.999rem){@layer components{.article-list-page{margin-bottom:calc(var(--spacing)*4);gap:calc(var(--spacing)*4);grid-template-columns:repeat(4,minmax(0,1fr));display:grid}.article-list-page>div{width:100%}}}@media (min-width:40rem) and (max-width:79.999rem){@layer components{.article-list-page{margin-bottom:calc(var(--spacing)*4);gap:calc(var(--spacing)*4);grid-template-columns:repeat(12,minmax(0,1fr));display:grid}.article-list-page>div{width:100%}}}@media (min-width:80rem){@layer components{.article-list-page>div:nth-of-type(n+1){display:block}.article-list-page{margin-bottom:calc(var(--spacing)*4);gap:calc(var(--spacing)*6);grid-template-columns:repeat(12,minmax(0,1fr));display:grid}}}@property --tw-blur{syntax:"*";inherits:false}@property --tw-brightness{syntax:"*";inherits:false}@property --tw-contrast{syntax:"*";inherits:false}@property --tw-grayscale{syntax:"*";inherits:false}@property --tw-hue-rotate{syntax:"*";inherits:false}@property --tw-invert{syntax:"*";inherits:false}@property --tw-opacity{syntax:"*";inherits:false}@property --tw-saturate{syntax:"*";inherits:false}@property --tw-sepia{syntax:"*";inherits:false}@property --tw-drop-shadow{syntax:"*";inherits:false}@property --tw-drop-shadow-color{syntax:"*";inherits:false}@property --tw-drop-shadow-alpha{syntax:"<percentage>";inherits:false;initial-value:100%}@property --tw-drop-shadow-size{syntax:"*";inherits:false}@property --tw-font-weight{syntax:"*";inherits:false}@property --tw-leading{syntax:"*";inherits:false}@property --tw-gradient-position{syntax:"*";inherits:false}@property --tw-gradient-from{syntax:"<color>";inherits:false;initial-value:#0000}@property --tw-gradient-via{syntax:"<color>";inherits:false;initial-value:#0000}@property --tw-gradient-to{syntax:"<color>";inherits:false;initial-value:#0000}@property --tw-gradient-stops{syntax:"*";inherits:false}@property --tw-gradient-via-stops{syntax:"*";inherits:false}@property --tw-gradient-from-position{syntax:"<length-percentage>";inherits:false;initial-value:0%}@property --tw-gradient-via-position{syntax:"<length-percentage>";inherits:false;initial-value:50%}@property --tw-gradient-to-position{syntax:"<length-percentage>";inherits:false;initial-value:100%}@property --tw-duration{syntax:"*";inherits:false}@property --tw-ease{syntax:"*";inherits:false}@property --tw-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-shadow-color{syntax:"*";inherits:false}@property --tw-shadow-alpha{syntax:"<percentage>";inherits:false;initial-value:100%}@property --tw-inset-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-inset-shadow-color{syntax:"*";inherits:false}@property --tw-inset-shadow-alpha{syntax:"<percentage>";inherits:false;initial-value:100%}@property --tw-ring-color{syntax:"*";inherits:false}@property --tw-ring-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-inset-ring-color{syntax:"*";inherits:false}@property --tw-inset-ring-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-ring-inset{syntax:"*";inherits:false}@property --tw-ring-offset-width{syntax:"<length>";inherits:false;initial-value:0}@property --tw-ring-offset-color{syntax:"*";inherits:false;initial-value:#fff}@property --tw-ring-offset-shadow{syntax:"*";inherits:false;initial-value:0 0 #0000}@property --tw-border-style{syntax:"*";inherits:false;initial-value:solid}@property --tw-tracking{syntax:"*";inherits:false}@property --tw-translate-x{syntax:"*";inherits:false;initial-value:0}@property --tw-translate-y{syntax:"*";inherits:false;initial-value:0}@property --tw-translate-z{syntax:"*";inherits:false;initial-value:0}@property --tw-rotate-x{syntax:"*";inherits:false}@property --tw-rotate-y{syntax:"*";inherits:false}@property --tw-rotate-z{syntax:"*";inherits:false}@property --tw-skew-x{syntax:"*";inherits:false}@property --tw-skew-y{syntax:"*";inherits:false}@property --tw-space-y-reverse{syntax:"*";inherits:false;initial-value:0}@property --tw-space-x-reverse{syntax:"*";inherits:false;initial-value:0}@property --tw-outline-style{syntax:"*";inherits:false;initial-value:solid}@property --tw-ordinal{syntax:"*";inherits:false}@property --tw-slashed-zero{syntax:"*";inherits:false}@property --tw-numeric-figure{syntax:"*";inherits:false}@property --tw-numeric-spacing{syntax:"*";inherits:false}@property --tw-numeric-fraction{syntax:"*";inherits:false}@keyframes spin{to{transform:rotate(360deg)}}@keyframes pulse{50%{opacity:.5}}@keyframes enter{0%{opacity:var(--tw-enter-opacity,1);transform:translate3d(var(--tw-enter-translate-x,0),var(--tw-enter-translate-y,0),0)scale3d(var(--tw-enter-scale,1),var(--tw-enter-scale,1),var(--tw-enter-scale,1))rotate(var(--tw-enter-rotate,0));filter:blur(var(--tw-enter-blur,0))}}@keyframes exit{to{opacity:var(--tw-exit-opacity,1);transform:translate3d(var(--tw-exit-translate-x,0),var(--tw-exit-translate-y,0),0)scale3d(var(--tw-exit-scale,1),var(--tw-exit-scale,1),var(--tw-exit-scale,1))rotate(var(--tw-exit-rotate,0));filter:blur(var(--tw-exit-blur,0))}}@keyframes accordion-down{0%{height:0}to{height:var(--radix-accordion-content-height)}}@keyframes accordion-up{0%{height:var(--radix-accordion-content-height)}to{height:0}}@keyframes progress{0%{transform:scaleX(0)}to{transform:scaleX(1)}}