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Although full suppression of HIV replication is always the goal of antiretroviral therapy, the reality is that many patients are unable to sustain this result long-term. Ongoing viral replication in the face of continued antiretroviral treatment generates resistance mutations that compromise treatment efficacy and that may also lead to cross-resistance to other agents. Accordingly, switching treatment is generally the preferred strategy when virologic suppression is not achieved. In some patients, however, immune function improves (as measured by CD4-cell count) despite the ongoing HIV replication, and if treatment options are limited, these patients might continue their present regimens instead of switching. A new retrospective study, spon…