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In December 2006, two large randomized trials of male circumcision were halted when the Data and Safety Monitoring Boards concluded that circumcision dramatically lowered the incidence of HIV infection among men (ACC Dec 22 2006). Now, investigators have published the 24-month results of both studies.
In the first study, 2784 HIV-negative men in Kenya (age range, 18–24) were randomized to circumcision or to a wait list. During follow-up, seroconversion occurred among 22 men in the circumcision group and 47 in the control group, yielding 2-year incidence rates of 2.1% and 4.2%, respectively. In an intent-to-treat analysis, circumcision was associated with a 53% reduction in risk for HIV infection. In an as-treated analysis, the magnitude of r…