Chronic Renal Insufficiency in HIV-Infected Patients

Despite extensive exposure to a variety of antiretrovirals, including indinavir and tenofovir, fewer than 5% of patients in a large cohort study had chronic renal insufficiency.

The prevalence of chronic renal insufficiency in patients with HIV infection and the role of antiretroviral medications in its development are somewhat unclear. Tenofovir, in particular, is associated with renal dysfunction, but the significance of this in clinical practice has not been well defined. In this cross-sectional analysis from the EuroSIDA cohort study, investigators evaluated potential risk factors for chronic renal insufficiency among 4474 HIV-infected patients who had at least two serum creatinine measurements during or after 2004.

Depending on the method used to estimate the glomerular filtration rate (GFR), 3.5% to 4.7% of patients had chronic renal insufficiency (defined as GFR ≤60 mL/min per 1.73 m²). As expected, these pat…

Reviewing Author

Sonia Nagy Chimienti, MD

Chronic Renal Insufficiency in HIV-Infected Patients

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Reviewing Author