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Rapid tests are often preferred for HIV screening because they are easy to perform, are relatively inexpensive, and provide highly accurate results in approximately 20 minutes. In many resource-limited settings, sequential rapid tests have become the standard for HIV diagnosis. To evaluate the accuracy of this approach, investigators examined testing data from 1517 men (age range, 15–49 years) who were screened for HIV infection as part of the enrollment process for two circumcision trials in Rakai, Uganda.
All the men provided blood samples that were initially tested with Determine HIV-1/2/O. Men with negative results were considered to be HIV-uninfected, and those with reactive results had their samples retested using HIV 1/2 STAT-PAK Ultr…