Viral Rebound Rates Decrease over Time in Suppressed Patients

In a U.K.-based cohort study, viral rebound rates fell over time among patients achieving plasma HIV RNA levels ≤50 copies/mL; after 4 years of continuous suppression, rates were similar in patients with and without a history of treatment failure.

Clinicians and patients commonly ask about the risk for viral rebound once a person has achieved full suppression of HIV replication. Currently, most of the information available on this topic derives from analysis of breakthrough rates for suppressed patients on their first regimen. Now, using data from the United Kingdom Collaborative HIV Cohort study, researchers have compared rebound rates for suppressed patients with and without a history of treatment failure.

Among 12,648 patients who received potent combination antiretroviral therapy (ART) from any of the seven participating HIV clinics, 10,237 (81%) achieved a viral load ≤50 copies/mL. A total of 2460 rebound events (defined as 2 consecutive plasma HIV RNA levels ≥400 copies/mL, or 1…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Viral Rebound Rates Decrease over Time in Suppressed Patients

Topics

Reviewing Author