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Transmitted resistance is well documented, but its influence on treatment outcome is still debated. In the present analysis, researchers describe the effect of transmitted resistance on virologic response in a large prospective clinical trial.
FTC-301A was an industry-sponsored, randomized, double-blind, multicenter trial that compared once-daily FTC with twice-daily d4T among treatment-naive patients who were receiving a background regimen of ddI plus efavirenz. As previously reported (ACC Oct 1 2004), the primary results of this study favored the FTC arm, with virologic failure occurring at week 60 in 4.3% of the FTC arm and 12.4% of the d4T arm. Genotypic and phenotypic analyses were performed on baseline samples and at the time of virolo…