Another Study on Tenofovir and Kidney Function

A nonrandomized study with substantial allocation bias showed clinically irrelevant differences in creatinine clearance among patients receiving tenofovir with a boosted PI, compared to those receiving either tenofovir with an NNRTI or non–tenofovir-containing regimens.

Two acyclic nucleosides, adefovir and cidofovir, are known to cause cumulative dose-dependent renotubular toxicity. Of concern is whether the structurally similar, but more widely used, tenofovir has similar effects. To address this issue, investigators compared glomerular filtration rates (GFRs) among three groups of patients: those receiving tenofovir with a boosted PI, those receiving tenofovir with an NNRTI, and those receiving antiretrovirals other than tenofovir. The 146 patients in this analysis were part of a larger study of therapeutic drug monitoring and had serum creatinine values available at baseline and at week 48 of therapy. GFRs were estimated using standard methods.

During the first 24 weeks of therapy, estimated creatinine …

Reviewing Author

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Another Study on Tenofovir and Kidney Function

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Reviewing Author