VA Study: ART Confers Negligible Risk for Heart Disease

Four-year follow-up of more than 40,000 HIV-infected patients revealed no association between longer durations of ART exposure and risk for cardiovascular disease.

Many antiretroviral regimens have been associated with metabolic perturbations that are linked to risk for atherosclerotic heart disease. Consequently, there is keen interest in determining the rates of cardiovascular events among HIV-infected patients. The first major paper on this subject came from the U.S. Veterans Affairs (VA) system and reported no increased cardiovascular risk with antiretroviral therapy (ART; ACC Apr 1 2003); however, two later reports from the DAD study linked higher rates of cardiovascular disease with increased exposure to ART and, specifically, to PIs (ACC Jan 1 2004 and Apr 25 2007). Now, investigators provide an update on the experience in the VA system.

Data were analyzed from 41,213 HIV-infected patients who w…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

VA Study: ART Confers Negligible Risk for Heart Disease

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Reviewing Author