Both Fish Oil and Fibrates Reduce Triglyceride Levels

Both fish oil and fenofibrate safely reduce elevated triglyceride levels in HIV-infected patients receiving ART.

High triglyceride levels are common among HIV-infected patients receiving potent antiretroviral therapy (ART) and may increase their risk for coronary artery disease. Fish oil and fibrates have each been shown to reduce triglyceride levels in HIV-infected patients, but few comparative data are available.

To address this gap, ACTG investigators conducted a randomized trial among 100 HIV-infected patients receiving ART who, despite dietary interventions, had fasting serum triglyceride levels ≥400 mg/dL and LDL cholesterol levels ≤160 mg/dL. Patients were randomized to receive fish oil (3 g twice daily) or fenofibrate (160 mg once daily) for 8 weeks, at which point they were evaluated for response. Those who did not achieve triglyceride levels …

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Both Fish Oil and Fibrates Reduce Triglyceride Levels

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Reviewing Author