Durability of Initial Antiretroviral Regimens in the Swiss HIV Cohort

ART success rates have improved over time — currently, more than 90% of patients achieve viral suppression at 1 year — but switching because of intolerance remains common.

HIV treatment guidelines are updated regularly to reflect new data on efficacy and toxicity. What constitutes a preferred regimen for initial antiretroviral therapy (ART) is a major focus of these updates. Although many combinations can suppress HIV replication successfully, optimal regimens provide durable responses that require minimal drug changes. As part of the Swiss HIV Cohort Study (which follows most HIV-infected patients in the country), investigators evaluated the durability of antiretroviral regimens among 1866 patients who initiated ART between 2000 and 2005.

The proportion of patients who changed regimens in the first year of treatment was nearly constant over time: 48.8% in 2000–2001, 43.8% in 2002–2003, and 44.3% in 2004–2005.…

Reviewing Author

Charles B. Hicks, MD

Disclosures

Consultant / Advisory boardGilead Sciences; ViiV; Merck

RoyaltiesUpToDate, Inc.

Grant / Research supportNIH; Department of Health and Human Services

Charles B. Hicks, MD

Disclosures

Consultant / Advisory boardGilead Sciences; ViiV; Merck

RoyaltiesUpToDate, Inc.

Grant / Research supportNIH; Department of Health and Human Services

Durability of Initial Antiretroviral Regimens in the Swiss HIV Cohort

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Reviewing Author