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Studies suggest that the availability of effective antiretroviral therapy (ART) has increased high-risk behavior, possibly because infected individuals feel less obligated to prevent transmission of what they perceive to be an easily treatable infection. Individuals who receive intermittent therapy may pose a greater risk for transmission than those on continuous therapy because of viremia during treatment interruptions. Do these individuals engage in the same high-risk behaviors as do individuals who receive continuous therapy? Researchers attempted to answer this question in a substudy of the SMART trial.
A total of 883 study participants, evenly divided between those taking continuous ART and those taking CD4-cell count–guided intermitten…