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Tuberculosis remains the most common HIV-related opportunistic infection (OI) worldwide. As with other OIs, the optimal time to start antiretroviral therapy (ART) in patients with TB is unknown. At this year’s Retrovirus Conference, Salim Abdool Karim presented important partial results from the SAPiT trial in South Africa [Abstract 36a; previously reported in JW AIDS Clin Care Sep 29 2008].
A total of 642 patients with TB and HIV infection were enrolled between June 2005 and July 2008 and were randomized to one of three strategies:
Early integrated treatment: ART was initiated during the intensive four-drug phase of TB treatment.
Late integrated treatment: ART was initiated after the intensive phase of TB treatment.
Sequential treatment: ART w…