Mortality Risk Varies Widely Across AIDS-Defining Events

Mortality hazard ratios (comparing risk among patients with a given AIDS-defining event to risk among HIV-infected patients without any event) ranged from 1.1 for herpes simplex disease to 17.6 for non-Hodgkin lymphoma.

Even with the advent of potent antiretroviral therapy (ART), deaths from AIDS-defining events still occur, particularly in patients who start treatment at low CD4-cell counts. However, some AIDS-defining events carry higher mortality risks than others. To quantify those risks, investigators pooled prospective data from 31,620 patients (participating in 15 clinical cohorts) who had no prior AIDS diagnoses when they initiated potent ART.

During a median follow-up of 43 months, AIDS-defining events were diagnosed in 2262 patients (7.2%); 1146 patients died, including 377 with AIDS-defining events. The most common AIDS-defining events were esophageal candidiasis, Pneumocystis jirovecii pneumonia, and Kaposi sarcoma. Overall, AIDS-defining events…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Mortality Risk Varies Widely Across AIDS-Defining Events

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Reviewing Author