Inflammatory Biomarkers and Risk for Opportunistic Disease

Higher levels of IL-6 and hsCRP at baseline and over time were associated with the development of opportunistic disease in the SMART study.

In a previous analysis from the SMART study, elevated baseline levels of the biomarkers D-dimer and interleukin (IL)-6 were associated with increased risk for death (JW AIDS Clin Care Nov 24 2008). However, most of the deaths in the SMART study were not caused by traditional AIDS-related opportunistic diseases (ODs), leaving open the question of whether inflammation and coagulation biomarkers influence the risk for such diseases.

Now, SMART investigators have conducted a nested case-control study to answer this question, using data from 91 study participants who developed ODs and 182 matched controls who did not. The biomarkers assessed included high-sensitivity C-reactive protein (hsCRP), IL-6, amyloid A, amyloid P, D-dimer, and prothrombin…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Inflammatory Biomarkers and Risk for Opportunistic Disease

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Reviewing Author