hsCRP Levels and CVD Risk Factors in Patients on ART

In a cohort of patients with virologic suppression and low estimated cardiovascular risk, hsCRP levels were elevated and were associated with increased BMI and lipid abnormalities.

Chronic immune activation and inflammation are believed to contribute to the increased cardiovascular risk often seen among HIV-infected individuals. Markers for chronic inflammation that are linked to cardiovascular risk, such as high-sensitivity C-reactive protein (hsCRP), are therefore of great interest. In this prospective cohort study, researchers assessed whether hsCRP levels were associated with various metabolic parameters in HIV-infected patients receiving potent combination antiretroviral therapy (ART).

Ninety-four patients were included in the study (median age, 44; 73% men; 57% white). The median nadir CD4 count was 190 cells/mm³, and the median duration of ART at enrollment was 790 days. About one third of patients had some leve…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

hsCRP Levels and CVD Risk Factors in Patients on ART

Topics

Reviewing Author