Prevalence and Incidence of HBV Infection in an HIV-Positive Cohort

Hepatitis B virus infection continues to be a major problem in a U.S. military cohort of HIV-infected individuals. More effective “prevention for positives” is needed.

Liver disease is highly prevalent among HIV-infected patients and is a leading cause of non–AIDS-related mortality. In this report, investigators explore the epidemiology of a common, treatable cause of liver disease — hepatitis B virus (HBV) infection — among 2769 HIV-infected individuals participating in the U.S. Military HIV Natural History Study.

Patients were defined as having HBV infection if they met any of the following criteria:

Concurrently positive for hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (HBcAb)
Concurrently positive for HBcAb and hepatitis B surface antibody (HBsAb)
Positive for either HBsAg or HBcAb on two separate occasions

Chronic HBV infection was defined as having a positive HBsAg on two separate bl…

Reviewing Author

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Prevalence and Incidence of HBV Infection in an HIV-Positive Cohort

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Reviewing Author