More from the DAD Study on Antiretrovirals and MI Risk

An increased risk for myocardial infarction was found with recent exposure to abacavir and ddI and with cumulative exposure to abacavir, indinavir, and lopinavir/ritonavir.

The DAD study has contributed significantly to our understanding of the long-term consequences of antiretroviral therapy (ART). Previous analyses from this study have shown an increased risk for myocardial infarction (MI) with longer exposure to ART in general and, more specifically, with PI exposure and recent use of ddI and abacavir (JW AIDS Clin Care Apr 25 2007 and Apr 14 2008). In this updated analysis, DAD investigators evaluated the MI risk associated with 13 different antiretrovirals (those for which patients in the cohort had accumulated >30,000 person-years of exposure).

A total of 580 MIs occurred during >178,000 person-years of follow-up, for an overall rate of 3.2 events per 1000 person-years. After adjustment for a host of pote…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

More from the DAD Study on Antiretrovirals and MI Risk

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Reviewing Author