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Numerous studies at the 2010 Conference on Retroviruses and Opportunistic Infections addressed the “non-AIDS” complications of HIV infection and antiretroviral therapy, although teasing apart the contributions of each is sometimes difficult.
In a cohort study involving nearly 7000 HIV-infected patients, Ole Kirk and colleagues examined potential risk factors for chronic kidney disease, which was defined as a decline in the estimated glomerular filtration rate (eGFR) to ≤60 mL/minute/1.73 m2 or, if the baseline GFR was already below that value, a decline of 25% or more [Abstract 107LB]. Overall, 225 patients (3.3%) progressed to chronic kidney disease. Tenofovir and indinavir were found to be associated with increased risk, as were, surprisin…