Pregnancy rates seem to be higher among HIV-infected women who have initiated antiretroviral therapy than among those who have not.
More than 2 million HIV-infected women in low- and middle-income countries are now receiving antiretroviral therapy (ART), but little is known about how such therapy might influence pregnancy rates. To address this issue, investigators analyzed data from a multinational care program that served more than 4500 HIV-infected women in sub-Saharan Africa between February 2003 and January 2007. ART was provided according to national or WHO guidelines.
A total of 589 pregnancies occurred during 7565 person-years of follow-up, for an overall incidence rate of 7.8 per 100 person-years. Approximately 40% of the pregnancies occurred before women started ART, and 60% occurred afterward. In a multivariate analysis, ART use was significantly associated wi…
Reviewing Author
DisclosuresConsultant/Advisory BoardUNAIDS; WHO; Bill and Melinda Gates Foundation, Population Council
Grant/Research SupportNIH; National Institute of Allergy and Infectious Diseases; Tides Foundation/MAC AIDS Fund; USAID; South African National Research Foundation; European Union; South African Medical Research Council
Editorial BoardsNew England Journal of Medicine; AIDS Reviews; AIDS Research and Human Retroviruses; mBio; Indian Journal of Medical Research; JAIDS: Journal of Acquired Immune Deficiency Syndromes
DisclosuresConsultant/Advisory BoardUNAIDS; WHO; Bill and Melinda Gates Foundation, Population Council
Grant/Research SupportNIH; National Institute of Allergy and Infectious Diseases; Tides Foundation/MAC AIDS Fund; USAID; South African National Research Foundation; European Union; South African Medical Research Council
Editorial BoardsNew England Journal of Medicine; AIDS Reviews; AIDS Research and Human Retroviruses; mBio; Indian Journal of Medical Research; JAIDS: Journal of Acquired Immune Deficiency Syndromes