How Often Do Anal Warts Harbor High-Grade Neoplasia or Cancer?

Among men who have sex with men, high-grade lesions were frequently present within anal condylomata that seemed benign on clinical exam.

Human papillomavirus (HPV) infection in the anogenital tract can include a mix of low- and high-risk HPV types. The low-risk types are associated with anogenital condylomata, whereas the high-risk types are associated with high-grade anal intraepithelial neoplasia (AIN) and anal squamous cell cancer. In this retrospective cohort study, investigators report the prevalence of high-grade AIN and anal cancer among 319 men who underwent surgical ablation of anal condylomata. All the men reported having sex with men, and half were HIV-positive.

Histopathologic testing revealed high-grade AIN or anal cancer in 37% of patients overall, but the proportion differed significantly by HIV serostatus: 47% in HIV-positive men versus 26% in HIV-negative men…

Reviewing Author

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

How Often Do Anal Warts Harbor High-Grade Neoplasia or Cancer?

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Reviewing Author