Renal Dysfunction in HIV: What's the Role of Antiretrovirals?

Tenofovir, indinavir, atazanavir, and lopinavir/ritonavir each increased the risk for chronic kidney disease, but for most of these agents, the excess risk disappeared shortly if not immediately after discontinuation.

Declining renal function continues to be a problem for many HIV-infected patients, even in the era of potent combination antiretroviral therapy. To determine whether specific antiretrovirals might be contributing to this problem, investigators evaluated data from the large, prospective EuroSIDA cohort study.

The analysis involved 6843 HIV-infected patients who had their height, weight, and serum creatinine levels measured at least three times after January 1, 2004. Estimated glomerular filtration rates (eGFRs) were calculated using the Cockcroft-Gault equation. Patients were considered to have developed chronic kidney disease (CKD) if their eGFR was ≤60 mL/minute/1.73 m² on at least two occasions ≥3 months apart — or if their eGFR was ≤60 mL…

Reviewing Author

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Renal Dysfunction in HIV: What's the Role of Antiretrovirals?

Topics

Reviewing Author