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Last week, we asked whether you would recommend a treatment change for an HIV-infected patient new to your practice. The patient's virus was well controlled, but he was experiencing treatment-related side effects, his regimen was cumbersome, and no resistance testing was available. So far, readers have been split on whether to advise a switch. Now, two experts describe what they would do.
A 55-year-old man transfers his care to your practice, having recently moved from another city. His current regimen consists of tenofovir (300 mg once daily), lopinavir/ritonavir (3 tablets twice daily), and efavirenz (600 mg once daily); he takes the lopinavir/r and tenofovir with food to reduce gastrointestinal upset, and he takes the efavirenz on…