Which Statins Are Best for Treating HIV-Related Dyslipidemia?

In an observational study, atorvastatin and rosuvastatin were more effective than pravastatin, with similar toxicity rates.

Dyslipidemia is common in HIV-infected patients and is typically characterized by high LDL cholesterol levels, high triglyceride levels, and low HDL cholesterol levels. Statins are the main agents used to reduce LDL levels, but little is known about their comparative effectiveness in HIV-infected patients.

To address this issue, investigators reviewed data from 700 HIV-infected patients who initiated statin therapy between 2000 and 2008. The cohort (85% men; mean age, 43) had an average 10-year cardiovascular risk of 10% and an average CD4-count nadir of 182 cells/mm³. Forty-three percent were receiving protease inhibitors, and 25% were receiving nonnucleoside reverse transcriptase inhibitors; the remainder were not on antiretroviral therapy…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Which Statins Are Best for Treating HIV-Related Dyslipidemia?

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Reviewing Author