Few New AIDS Events Despite Incomplete Immune Recovery

In a large cohort of patients who achieved sustained virologic control on ART, incomplete immune recovery was a significant predictor of new AIDS-defining events, but the overall risk was low and diminished further with prolonged follow-up.

Several studies have documented poor clinical outcomes among patients who have incomplete immune recovery on antiretroviral therapy (ART) despite sustained virologic control. Most studies, however, suffer from a small sample size or limited follow-up. In the present investigation, researchers evaluated the incidence of AIDS-defining events among 1318 patients who commenced ART at CD4 counts <200 cells/mm³ and, within 6 months, achieved virologic suppression to <50 copies/mL.

Sixty-four percent of the cohort had an early immune response (defined as a CD4 count ≥200 cells/mm³ within 6 months of virologic suppression), whereas 8% continued to have CD4 counts <200 cells/mm³ for at least 24 months despite virologic suppression. Such prolonged imm…

Reviewing Authors

Lauren E. Ivey

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Few New AIDS Events Despite Incomplete Immune Recovery

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Reviewing Authors