Transmitted Drug Resistance and Response to Antiretroviral Therapy

Among patients initiating combination ART, the risk for virologic failure was three times higher among those whose regimens contained a drug they were resistant to than among those without resistance or those who initiated a fully active regimen despite resistance.

An estimated 10% to 15% of treatment-naive HIV-infected patients carry viruses that are resistant to at least one antiretroviral drug. Transmitted resistance can influence virologic and immunologic response to treatment, but the effects have been difficult to quantify. To address this issue, researchers analyzed data from 10,056 treatment-naive patients in Europe who underwent baseline genotypic resistance testing before initiating antiretroviral therapy (ART) between 1998 and 2008.

Approximately 90% of the patients had no evidence of transmitted resistance, 5% had at least one mutation but still received a fully active regimen, and 5% had resistance to at least one drug in the regimen they received. After 1 year of therapy, virologic failur…

Reviewing Authors

Arash Poursina, MD

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Transmitted Drug Resistance and Response to Antiretroviral Therapy

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Reviewing Authors