Predicting Long-Term CD4-Cell Counts and Viral Loads

Pretreatment CD4-cell count, age at initiation of therapy, and early treatment response are strong predictors of CD4-cell recovery and virologic suppression 5 to 12 years after ART initiation.

Very few studies have examined CD4-cell counts and viral loads in patients on long-term potent antiretroviral therapy (ART). Here, researchers evaluate data from 614 men in the MACS cohort who had been taking ART consistently for 5 to 12 years.

At the time of ART initiation, 12% of the men were aged 50 and older, 40% were antiretroviral-naive, and more than 50% had CD4 counts ≤350 cells/mm³ and viral loads ≥10,000 copies/mL. After 5 to 12 years of ART, the median CD4 count was 585 cells/mm³, and viral loads were undetectable at 78% of study visits. Multivariate analyses revealed the following:

Pretreatment CD4-cell counts ≤500 cells/mm³ and age ≥50 at ART initiation were both associated with lower long-term CD4-cell counts. Among patients who…

Reviewing Author

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Predicting Long-Term CD4-Cell Counts and Viral Loads

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Reviewing Author