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HIV-infected individuals, including those with complete virologic suppression, have persistently elevated levels of proinflammatory cytokines and other markers suggestive of ongoing chronic inflammation and immune activation. Does this observation explain the elevated risk for malignancy and organ failure that is seen in HIV-infected patients despite effective treatment — and, if so, would the broad anti-inflammatory effects of a statin help?
Investigators retrospectively evaluated the link between statin use and overall mortality risk among 1538 patients at the Johns Hopkins HIV clinic who initiated antiretroviral therapy (ART) between 1998 and 2009 and achieved virologic suppression shortly thereafter. A total of 238 patients had received …