HIV and Clinical Manifestations of Accelerated Aging

As HIV-infected patients live longer, more are developing chronic diseases typical of aging — but they appear to be doing so earlier and at a higher rate than the general population.

Since the advent of potent antiretroviral therapy (ART), the primary causes of morbidity and mortality among HIV-infected patients have shifted from AIDS-related illnesses to the chronic noncommunicable conditions typically associated with aging. Two research groups recently described the epidemiology of these conditions in HIV-infected patients.

Guaraldi and colleagues evaluated the prevalence of noninfectious comorbidities among 2854 HIV-infected patients receiving ART in Italy (mean age, 46; 71% with undetectable viral loads; median duration of infection, 16 years; median nadir CD4 count, 170 cells/mm³; median current CD4 count, 520 cells/mm³) and 8562 HIV-uninfected controls matched for age and sex. Compared with the controls, the HIV-in…

Reviewing Author

Carlos del Rio, MD

HIV and Clinical Manifestations of Accelerated Aging

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Reviewing Author