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Many studies have confirmed that HIV-infected individuals are at risk for developing abnormally low bone-mineral density, regardless of whether they receive antiretroviral therapy (ART). But does this risk translate into a higher-than-normal rate of bone fractures?
Investigators sought to answer this question using two large national registries in Denmark: one that includes data on all HIV infections diagnosed since 1995 in Danish nationals older than age 16 years, and one that summarizes discharge diagnoses for all patients admitted to — or seen in the emergency rooms of — the nation's hospitals.
The 5306 HIV-infected individuals identified (median age, 37; 76% male; 78% receiving ART) sustained fractures at a rate 1.5 times that of age- and…