Can We Do Better at Predicting Survival in HIV Infection?

Adding renal, liver, and hematologic markers to age, CD4-cell count, and viral load modestly improved risk prediction. Further incremental improvements were seen with the addition of inflammatory biomarkers.

Assessing prognosis in HIV-infected patients is difficult because so many factors are at play. In the Veterans Aging Cohort Study (VACS), investigators have evaluated two different clinical indexes for predicting mortality: a restricted index, which incorporates three standard markers of mortality (age, CD4-cell count, and viral load), and the VACS index, which includes those standard markers as well as six routine measures of end-organ health status (creatinine levels, aspartate and alanine aminotransferase levels, hepatitis C virus [HCV] serostatus, platelet counts, and hemoglobin levels). In the present study, researchers compared the two indexes and also assessed the predictive value of adding nonroutine biomarkers of chronic inflammati…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Can We Do Better at Predicting Survival in HIV Infection?

Topics

Reviewing Author