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One-pill, once-daily regimens have been shown to improve adherence to antiretroviral therapy (ART). However, with these regimens, the consequences of missing a few pills may, at least in theory, be more significant than having similarly poor adherence to other regimens. Where do the clinical data weigh in?
Using a nationwide insurance database, researchers identified more than 7000 HIV-infected patients who were prescribed state-of-the-art combination ART between 2006 and 2008: 61% were given regimens composed of ≥3 pills daily, while 33% (with similar demographics and comorbidities) were given a single-pill, efavirenz-based regimen. Adherence was quantified as the extent to which the patient had a steady supply of all medications at home.
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