Low Nadir CD4-Cell Count Linked to Persistent Endothelial Dysfunction

Among HIV-infected patients doing well on antiretroviral therapy, a nadir CD4 count <350 cells/mm³ was the only clinical variable associated with endothelial dysfunction.

Numerous studies have suggested that HIV-infected individuals are at increased risk for cardiovascular disease. In this cross-sectional study, researchers evaluated nadir CD4-cell count, current CD4-cell count, and endothelial function among patients on stable antiretroviral therapy (ART), to better understand how earlier treatment initiation might influence long-term cardiovascular risk

Seventy-four men with undetectable viral loads on ART (median age, 47; 82% white) underwent noninvasive assessment of endothelial function using brachial artery flow-mediated dilation (FMD). Median current CD4 count was 659 cells/mm³, and median nadir CD4 count was 314 cells/mm³ (39 patients had nadir CD4 counts <350 cells/mm³). Traditional cardiovascular ri…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Low Nadir CD4-Cell Count Linked to Persistent Endothelial Dysfunction

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Reviewing Author