Does CMV Infection Mediate HIV-Associated Cardiovascular Disease?

High cytomegalovirus IgG titers correlated with carotid artery abnormalities in HIV-positive women, particularly those on suppressive antiretroviral therapy.

The link between cytomegalovirus (CMV) infection and accelerated cardiovascular disease has intrigued researchers for years, although clear proof of a cause-and-effect relationship remains elusive. Researchers have unearthed yet more intriguing but inconclusive data from the ongoing, prospective, multicenter WIHS cohort of HIV-positive and HIV-negative women.

A total of 601 HIV-positive, CMV-seropositive women (mean age, 41) had their CMV immunoglobulin G (IgG) levels quantitated and underwent carotid artery ultrasound testing to check for early evidence of cardiovascular disease. In a multivariate analysis adjusted for age, race/ethnicity, smoking, diabetes and body-mass index, higher CMV IgG levels were associated with increased carotid ar…

Reviewing Author

Abigail Zuger, MD

Disclosures

Nothing to disclose

Abigail Zuger, MD

Disclosures

Nothing to disclose

Does CMV Infection Mediate HIV-Associated Cardiovascular Disease?

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Reviewing Author