CD4 Discordance in HIV/HCV-Coinfected Patients

In patients coinfected with HIV and hepatitis C virus, the combination of a low CD4-cell count with a relatively well-preserved CD4 percentage is associated with ongoing HCV replication, advanced liver disease, and marked lymphopenia.

CD4-cell count and CD4 percentage are both important prognostic markers in HIV-infected patients and are routinely used to stage disease, assess the risk for disease progression or mortality, and evaluate the need for treatment initiation. In a previous study of HIV-uninfected adults, advanced liver disease was associated with CD4 discordance — specifically, a low CD4-cell count despite a relatively well-preserved CD4 percentage. Two recent studies describe the prevalence and correlates of CD4 discordance among patients with HIV and hepatitis C virus (HCV) coinfection.

Claassen and colleagues evaluated 287 HIV-infected adults (94% HCV-positive) in Baltimore, while Hull and colleagues evaluated 908 HIV/HCV-coinfected adults in Canada. Both gr…

Reviewing Authors

Kathryn M. Hollins

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

CD4 Discordance in HIV/HCV-Coinfected Patients

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Reviewing Authors