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Pre-exposure prophylaxis (PrEP) has been shown to be efficacious among men who have sex with men (MSM; JW AIDS Clin Care Nov 23 2010). This week, the New England Journal of Medicine published the results of three trials of PrEP among heterosexual populations in Africa:
Partners-PrEP, in which researchers tested oral tenofovir alone and oral tenofovir/FTC among 4747 heterosexual, HIV-serodiscordant couples
TDF2, in which researchers tested oral tenofovir/FTC among 1219 heterosexual men and women
FEM-PrEP, in which researchers tested oral tenofovir/FTC among 2120 heterosexual women
In all three trials, HIV-negative individuals were randomized to receive daily oral PrEP or placebo, along with comprehensive HIV prevention services, and were assesse…