Diabetes + HIV = A Double Whammy for CKD

Chronic kidney disease is responsible for an increasing burden of disease in HIV-infected patients, driven in part by an increasing prevalence of diabetes in this population. In the present study, researchers evaluated the relative contributions of HIV infection and diabetes to the risk for chronic kidney disease.

Using data from the VACS Virtual Cohort, the investigators identified 31,072 U.S. veterans who had a baseline estimated glomerular filtration rate (eGFR) ≥45 mL/minute/1.73m² (mean, 94 mL/minute/1.73m²). About 34% of the veterans had HIV infection alone, 16% had diabetes alone, and 6% had both. The primary endpoint was a decrease in eGFR to <45 mL/minute/1.73m² on at least two separate measurements ≥90 days apart.

During a median fo…