In this systematic review and meta-analysis, the prevalence of HIV drug resistance among treatment-naive HIV-infected individuals increased annually by 29% in east Africa and by 14% in southern Africa.
The last decade has witnessed a dramatic scale-up of antiretroviral therapy (ART) in low- and middle-income countries. In developed regions of the world, increases in ART coverage have been mirrored by increasing rates of transmitted drug resistance. Is the same true in resource-limited settings?
Researchers conducted a systematic review and meta-analysis to estimate changes in the prevalence of HIV drug resistance among treatment-naive HIV-infected individuals following ART rollout. From 2001 through 2011, they identified 162 reports spanning 42 countries, which they combined with 27 datasets from the WHO HIV drug-resistance surveillance program. More than 20,000 treatment-naive patients from sub-Saharan Africa and Latin America were includ…