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Hypertrophic cranial pachymeningitis — a disorder characterized by diffuse thickening of the dura mater and manifest by chronic daily headaches, with or without associated neurological deficits — has many possible etiologies. HIV infection may be one of them, according to a new case report.
The case patient was an HIV-infected woman with a nadir CD4 count of 6 cells/mm3 who developed chronic, recurrent headaches after 3 years of lopinavir/ritonavir monotherapy. (She had originally been treated with triple-drug antiretroviral regimens but experienced adverse effects from nucleoside and nonnucleoside reverse transcriptase inhibitors.) Magnetic resonance imaging (MRI) results were consistent with pachymeningitis.
Analysis of the cerebrospinal fl…