Markers of Inflammation and Coagulation Linked to Cardiovascular Risk in HIV-Infected Patients

In the SMART study, increased baseline levels of interleukin-6, D-dimer, and high-sensitivity C-reactive protein were independently associated with the development of cardiovascular disease.

HIV infection is thought to be a major risk factor for cardiovascular disease (CVD), largely because of the immune activation and inflammation that are characteristic of the infection. In a recent analysis from the SMART study, researchers evaluated whether baseline levels of inflammation and coagulation — as measured by interleukin (IL)-6, D-dimer, and high-sensitivity C-reactive protein (hsCRP) — were associated with CVD risk over time.

A total of 5098 study participants had stored plasma samples available from baseline. Of these, 252 experienced a cardiovascular event (CVD death, nonfatal myocardial infarction, nonfatal stroke, congestive heart failure, coronary revascularization, coronary artery disease requiring drug treatment, or perip…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Markers of Inflammation and Coagulation Linked to Cardiovascular Risk in HIV-Infected Patients

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Reviewing Author