Rates of Transmitted HIV Drug Resistance Rising in the U.S.

The increase is driven primarily by resistance to nonnucleoside reverse transcriptase inhibitors.

Accurate epidemiologic surveillance of transmitted HIV drug resistance has important implications for both recommendations of first-line antiretroviral therapy (ART) and community efforts to prevent such resistance. Investigators recently evaluated the changing rates of transmitted HIV drug resistance among 720 patients with acute or chronic infection in the southeastern U.S.

All the study participants presented for HIV care in North Carolina between 1999 and 2010 and had an HIV genotyping test prior to ART initiation. They were classified as acutely infected if they had a negative enzyme-linked immunosorbent assay (ELISA) or Western blot (WB) result either in combination with a positive HIV viral-load test or in the 45 days before a positiv…

Reviewing Author

Jonathan Z. Li, MD

Rates of Transmitted HIV Drug Resistance Rising in the U.S.

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Reviewing Author