The potential sources may predate the acquisition of HIV infection itself.
Low bone-mineral density (BMD), common in patients with HIV infection, has been attributed to the infection itself; antiretroviral therapy (ART); use of tobacco, alcohol, and recreational drugs; and various comorbidities that can lower BMD. Investigators in the Netherlands have now analyzed BMD and biomarkers relevant to bone metabolism among 177 men who have sex with men (MSM): 41 patients with primary HIV infection, 106 ART-naive patients with chronic HIV infection, and 30 unmatched HIV-negative controls. All the men were aged 20 to 55. Low BMD was common in all three groups.
Levels of several serum biomarkers, including those for bone resorption and bone formation, differed significantly between MSM with primary HIV infection and HIV-nega…
Reviewing Authors
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)
Ighovwerha Ofotokun, MD, MScR
Ighovwerha Ofotokun, MD, MScR