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Predictors found to correlate with adherence to antiretroviral therapy (ART) have encompassed both demographics (young age, black race, injection-drug use) and regimen characteristics (greater pill burden, higher dose frequency). In the largest analysis of adherence data to date, researchers have reexamined this issue.
Participants in the SMART study (a large multinational trial comparing continuous with intermittent ART, which ran from January 2002 to January 2006) were asked every 4 months to rate their adherence to each of their antiretroviral drugs: During the previous week, had they taken “all,” “most,” “about one-half,” “very few,” or “none” of their doses?
Of more than 35,000 responses from 5295 participants, 17% were classified as ind…