Higher Tenofovir Trough Concentrations and Renal Dysfunction

High trough levels of tenofovir, seen in half the patients taking the drug, were associated with renal impairment.

Tenofovir is a common component of current antiretroviral therapy (ART) regimens. It is excreted by the kidney and has been associated with a low risk for clinically significant renal dysfunction during the first years of use. In France, due to concern about the renal effects of tenofovir, concentrations of this drug are often monitored during the first 12 months of use. Now, investigators have retrospectively assessed the association between tenofovir trough concentrations and glomerular filtration rate (GFR) in HIV-infected patients on tenofovir-containing regimens who were seen at one clinic in France between December 2006 and January 2010.

The study involved 163 patients (median age, 47; 30% women; median CD4 count, 382 cells/mm³; 68% wi…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Higher Tenofovir Trough Concentrations and Renal Dysfunction

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Reviewing Author