Managing C. diff Infection in IBD

Clinical Takeaway

: New expert guidance from the American Gastroenterological Association

An overview of the AGA Clinical Practice Update on Management of Clostridioides difficile infection in Inflammatory Bowel Disease: Expert Review (2026)

Background

Patients with inflammatory bowel disease (IBD) experience Clostridioides difficile infection (CDI) and recurrence more frequently than patients without IBD, and CDI in this population is often more severe. This clinical practice update offers 12 “best practice advice” statements without formal assessment of strength of recommendations or quality of evidence.

Key Recommendations

Diagnosing and Treating CDI

Test for CDI in all patients with IBD and new or worsening diarrhea, regardless of recent exposure to antibiotics or prior colectomy.
Use a two-step test combining a high-sensitivity a…

Reviewing Author

Rahul B. Ganatra, M.D., M.P.H.

Disclosures

Grant/Research SupportVA Health Systems Research Evidence, Policy, and Implementation Center (EPIC) / Ambient Dictation Tech Sprint Evaluation Supplement

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