Updated Aspergillosis Guidelines for Solid Organ Transplantation Recipients

Clinical Takeaway

: In most instances, preventive therapy for invasive aspergillosis is not recommended for SOT recipients.

An overview of IDSA 2026 Clinical Practice Guideline Update on the Prevention of Invasive Aspergillosis in Adult Solid Organ Transplant Recipients

Background

The Infectious Diseases Society of America (IDSA) last issued guidelines for managing aspergillosis in 2016. These updated guidelines on invasive aspergillosis (IA) specifically cover solid organ transplantation (SOT): liver, kidney, pancreas, heart, and lung. Approaches include universal or targeted prophylaxis, preemptive therapy, and secondary prophylaxis.

Key Points

For liver transplant recipients, the guidelines disfavor universal IA prophylaxis and instead recommend targeted prophylaxis for recipients at high risk of IA (renal replacement therapy in the peritransplantation period, re…

Reviewing Author

Neil M. Ampel, M.D.

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)