ECG Abnormalities in Brugada Syndrome — What’s at the Heart of the Matter?

Brugada syndrome is characterized by type 1 electrocardiogram changes (J-point elevation ≥2 mm, coved and elevated ST-T segment, and inverted T-waves in leads V₁ and V₂) and at least one episode of ventricular fibrillation. These authors examined the effect of sodium blockade on endocardial, epicardial, and surface ECG morphology in 19 patients with Brugada syndrome and 3 controls to examine the hypothesis that differences in activation-recovery intervals in the endocardium and epicardium contribute to the ECG abnormalities.

Researchers used electrograms recorded by electrical guidewires introduced into the right ventricular outflow tract to measure activation-recovery intervals, activation times, and repolarization times directly in the end…