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Sugammadex is a novel agent designed to rapidly reverse rocuronium block (JW Emerg Med Mar 23 2007), but it has not been evaluated for reversal of the higher doses of rocuronium used for rapid sequence intubation (RSI). In a multicenter European study, investigators (including a clinical research scientist and statisticians employed by the manufacturer) randomized 168 patients who were undergoing elective anesthesia to receive one of five doses of sugammadex (2, 4, 8, 12, or 16 mg/kg) or placebo administered either 3 minutes or 15 minutes after administration of rocuronium (1.0 mg/kg or 1.2 mg/kg). Recovery of muscle function (to 90% of normal response to train-of-four stimulation, which permits normal breathing) was monitored continuously …