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Severe traumatic brain injury (TBI), defined as a head Abbreviated Injury Scale score ≥3, is associated with a high mortality rate, and development of coagulopathy might be a contributing factor. To study the relation between coagulopathy and severe TBI, researchers prospectively evaluated 436 patients (78% men) with severe TBI who were admitted to a single level I trauma center from June 2005 through May 2007.
Mechanism of injury was blunt in 392 patients and penetrating in 44; 387 patients had isolated severe TBI. The most common pathology was subarachnoid hemorrhage in patients with blunt trauma (44%) and intraparenchymal hemorrhage in those with penetrating trauma (68%). Coagulation studies were obtained at baseline and every 6 hours unt…