Hyperoxia After Cardiac Arrest Is Associated with Increased In-Hospital Mortality

Further research is needed to determine optimum oxygenation.

Recent studies have focused on management strategies for improving outcomes after return of spontaneous circulation in patients with cardiac arrest. These authors addressed the effects of postresuscitation oxygenation on mortality.

Researchers used a database of intensive care units (ICUs) at 120 hospitals to study 6326 patients who were older than 17 years, had nontraumatic cardiac arrest, received cardiopulmonary resuscitation (CPR), and underwent arterial blood gas analysis within 24 hours after ICU arrival. Patients were divided into three groups based on oxygenation on the first blood gas result: hyperoxia (PaO₂ ≥300 mm Hg; 18% of patients), hypoxia (PaO₂ <60 mm Hg or ratio of PaO₂ to fraction of inspired oxygen [FiO₂] <300; 63%), and n…

Reviewing Author

Diane M. Birnbaumer, MD, FACEP

Disclosures

Consultant / Advisory boardSecurisyn

Editorial boardsThe Merck Manuals (Home and Physician Editions)

Diane M. Birnbaumer, MD, FACEP

Disclosures

Consultant / Advisory boardSecurisyn

Editorial boardsThe Merck Manuals (Home and Physician Editions)